Year : 2014  |  Volume : 7  |  Issue : 1  |  Page : 32-39

The equisedative effect of dexmedetomidine versus propofol on supraclavicular brachial plexus block and recovery profile in patients with ischemic heart disease

1 Department of Anesthesiology and Intensive Care, Ain-Shams University, Cairo, Egypt
2 Department of Anesthesiology and Intensive Care, 6th of October University, Cairo, Egypt

Correspondence Address:
Rasha S Bondok
MD, Department of Anesthesiology and Intensive Care, Ain-Shams University, 33 Hassan Maamuon St, Nasr City 11391, Cairo
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1687-7934.128398

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Background The study investigated the effect of intraoperative equisedative doses of dexmedetomidine and propofol on supraclavicular nerve block in patients with ischemic heart disease. Patients and methods Patients with ischemic heart disease, American Society of Anesthesia (ASA) II-III, scheduled for upper-limb orthopedic surgery after an effective ultrasound-guided supraclavicular nerve block were included in this study. Patients were randomly allocated to receive dexmedetomidine 0.5 μg/kg or propofol 0.5 mg/kg as an initial loading dose for 10 min followed by a maintenance dose adjusted intraoperatively to a bispectral index of 70-80. In the postanesthesia care unit, the sedation score was recorded every 10 min until discharge. The degree of pain was evaluated hourly for the first 12 h and at 18 and 24 h postoperatively. Duration of analgesia and need of rescue analgesia were calculated. Results During recovery, hemodynamic variables were significantly high in group P compared with group D (P < 0.001). The duration of analgesia was significantly longer in group D compared with group P (11.81 ± 3.54 vs. 7.18 ± 3.21 h, P < 0.001) and requirement for rescue analgesia was significantly lower in group D (27% compared with 81% in group P, P < 0.001). Conclusion Dexmedetomidine may prove a valuable adjuvant for sedation and analgesia in ischemic heart patients undergoing surgery under regional block.

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