Persistent neurological impairment following spinal anesthesia with bupivacaine has rarely been reported. We report three cases of neurological deficits that persisted more than 3 days after an uncomplicated single intrathecal injection of 0.5% hyperbaric bupivacaine. The first two cases were female patients 39 and 37 years of age and who had received spinal anesthesia with bupivacaine to undergo dilatation and curettage and cesarean section, respectively. The third case was a 22-year-old male patient who received bupivacaine spinal anesthesia for right knee arthroscopy. MRI indicated no anatomical abnormality in any of these cases. Bupivacaine neurotoxicity was suggested by the absence of any other identifiable cause for these neurologic deficits. Corticosteroid was used to manage the cases, with a diverse outcome in each case.